Researchers from Charité – Universitätsmedizin Berlin and the Zuse Institute Berlin have developed a new generation of opioids that will only work at sites affected by injury or inflammation. These drugs can prevent the occurrence of brain- and gut-related side effects typically associated with conventional opioids and have been shown to be successful in preclinical studies. Results from this research have been published in Pain and Scientific Reports.

Opioids are a class of drugs used to treat pain, especially that associated with tissue damage and inflammation. Common side effects associated with their use include drowsiness, nausea, constipation, dependency, and, in some cases, respiratory arrest. The research team, which is led by Christoph Stein, MD, used computer simulations to develop two new opioids using fentanyl as the starting molecule.

The researchers hypothesized that damaged or inflamed tissues show stronger interaction between opioid agonists—the substances that elicit the pain-relieving effect—and the opioid receptors they bind to. Their computer simulations suggested that this is due to an increased concentration of protons in inflamed tissues, which leads to lower pH values than in healthy tissues, resulting in acidic conditions. Opioid molecules need to undergo protonation before they can bind to and activate opioid receptors. The researchers used this knowledge to design two drugs that would only exist in their protonated state in the presence of inflammation. This restricts opioid receptor activation to sites of tissue damage or inflammation, rather than receptors in the brain or gut.

“Our innovative design method provides a robust basis for a new generation of pain medications,” Stein reported. “These drugs could help us both to avoid the dangerous side effects of conventional opioids and to reduce complications. They would also help us stem the opioid crisis, a problem that is particularly evident in the United States.”

The researchers hope to further develop these newly designed drugs to make them available to patients. They also plan to enhance their understanding of the molecular processes underlying the complex interactions seen in inflamed tissues in the hope that they may be able to support opioid optimization through the insights they gain. Ideally, their insights will also be beneficial for other drugs.

This article was adapted from information provided by Charité – Universitätsmedizin Berlin.

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