The healing of wounded skin in people with diabetes can be sped up by more than 50 percent using injections of stem cells taken from bone marrow, a new study in mice shows.
The research, led by scientists at the New York University (NYU) School of Medicine, focused on a chain of events in diabetes that makes skin sores more likely to form and less likely to heal.
The body’s failure in diabetes to break down dietary sugar creates molecules called free radicals that can wreak havoc on cells and damage their DNA. These free radicals also trigger an inrush of immune cells and chemicals meant to fight infection that, researchers say, instead kill normal cells and cause diabetic skin ulcers. These wounds, they note, can take twice as long to heal as in healthy mammals and are prone to infection.
Published in the January issue of the journal Diabetes, the study showed that the injected stem cells restore a cell signaling pathway called Nrf2/Keap1, recently shown by the NYU team to be disrupted in diabetes. The rebalancing brought on by stem cell therapy, the researchers say, decreased wound healing time to 21 days in treated diabetic mice compared with 32 days in untreated diabetic mice. By contrast, normal mouse skin wounds usually heal in 14 days.
The early-stage stem cells used in the current study are the kind that have the potential to mature into more than one kind of cell, but then specialize to serve within a particular mammalian organ like the skin. While essential to the formation of the body in the womb, pools of stem cells also persist in the adult body, where they can be triggered to serve as replacement parts when tissues are damaged, the goal of regenerative medicine.
Previous research by the NYU team had shown that in human diabetes, stem cells do not contribute normally to tissue regeneration. This led the team to test what injections of donated stem cells, known to deter an immune response, might do to correct the dysfunction.
Ceradini says that if future experiments prove successful, his team’s stem cell therapy could help in healing not just diabetic skin ulcers but also in repairing damage to diabetes-inflamed blood vessels.
The Centers for Disease Control and Prevention’s latest figures show that more than 30 million Americans have diabetes, and researchers estimate that one in ten will develop some form of diabetic skin wound, typically a foot ulcer. Although rare, some of these can result in the need for amputation. Researchers have estimated the annual healthcare costs in the United States from skin wounds related to diabetes at more than $9 billion.
Study first author Piul Rabbani, PhD, said that “other than keeping wounds moist and covered,” there are few treatment options for diabetic skin ulcers. She cautions that, although several labs have reduced the inflammation behind skin ulcers in early experiments, clinical trials using stem cells are still several years away. Rabbani, a research assistant professor at NYU Langone, says the research team next plans to develop an experimental stem-cell-based therapy for testing in larger mammals.
This article was adapted from information provided by NYU Langone Health.
