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Researchers ?Shake Up? Bacteria to Defeat Infections

Robert Smith, PhD. Image courtesy of Robert Smith, PhD.

Bacteria are everywhere, but despite widespread belief, not all bacteria are bad. To combat those that can cause health issues for humans though, there has been an over-reliance on the use of antibiotics-so much so that many of them are now proving ineffective due to bacteria developing increased resistance to them.

“More and more antibiotics are essentially becoming useless,” said Robert Smith, PhD, assistant professor at Nova Southeastern University (NSU). “Even the most routine infections, such as ear infections that are often seen in children, are becoming more challenging and expensive to treat.”

This notion isn’t new-just prior to winning his Nobel Prize in 1945, Alexander Fleming, the scientist who discovered antibiotics, warned that overusing them would lead to bacteria that were no longer killed by these drugs. Since then, scientists and bacteria have been locked in a deadly arms race. While scientists rush to discover new antibiotics, bacteria fight back by developing new tools to resist them. In recent years, the bacteria have been winning.

This paradigm led researchers at NSU to take another look at how bacteria do what they do to see if there was another way to approach the issue. Researchers are now focusing on developing new ways to treat infections that reduce the use of antibiotics. The results from the NSU researchers, who worked with colleagues from Duke University and the University of Minnesota, are detailed in Scientific Reports.

One way that bacteria infect people is by working together. First, they build a home called a biofilm, and then they use chemicals to communicate with each other. This allows the bacteria to coordinate an attack on the infected person. Led by NSU graduate Cortney Wilson, MS, Smith’s lab recently discovered that by shaking the house that the bacteria have built, the ability of the bacteria to communicate is affected.

“We found that shaking the bacteria forced them to face a decision; do they want to grow, or do they want to cooperate,” Smith said. “And if we shook them at just the right frequency, we created enough confusion that the bacteria could do neither effectively.”

Smith notes that this strategy has promise in reducing the need for antibiotics. “It is a very exciting time for our research team. We are looking forward to building upon our very promising results and to moving our strategy into the clinic.”

This article was adapted from information provided by NSU.